J. Biomed. Inform. 2026 – Multimodal AI in healthcare: Review of vision-language foundation models for real-world medical applications

Taha Razzaq, Murtaza Taj, Asim Iqbal

Abstract:

\initial{T}\textbf{he emergence of foundation models has marked a transformative shift in AI, enabling robust generalization across diverse downstream tasks through putative zero-shot learning. Large Language Models and Vision-Language Models have demonstrated strong capabilities in tasks such as image interpretation, report generation, and question answering by effectively learning from multimodal data—images paired with associated text—often with minimal supervision. In the healthcare domain, this ability to align visual and textual information reduces the reliance on extensive manual annotations, as models can leverage existing clinical reports and imaging data to learn meaningful representations. This integration holds promise for improving diagnostic support, treatment planning, and overall patient care, even in data-constrained settings. In this review, we provide a definitive taxonomy of the medical VLM landscape, tracing the evolution from early Contrastive Alignment and Generative MLLMs to the cutting-edge frontiers of Dense Pixel-Grounding, Sparse Mixture-of-Experts (MoE), and Reasoning-Incentivized (RL) architectures. We critically examine the “medical bottleneck”—identifying the persistent challenges of data scarcity, the “hallucination” risks in generative diagnostics, the computational strain of 3D volumetric processing, and the lack of standardized, clinically-grounded evaluation metrics.

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Text Reference:

 Razzaq T, Taj M, Iqbal A. Multimodal AI in healthcare: Review of vision-language foundation models for real-world medical applications. J Biomed Inform. 2026 Jul 8;181:105075. doi: 10.1016/j.jbi.2026.105075. Epub ahead of print. PMID: 42419495.

Bibtex Reference:

@article{razzaq2026multimodal,
  title     = {Multimodal AI in healthcare: Review of vision-language foundation models for real-world medical applications},
  author    = {Razzaq, Taha and Taj, Murtaza and Iqbal, Asim},
  journal   = {Journal of Biomedical Informatics},
  volume    = {181},
  pages     = {105075},
  year      = {2026},
  publisher = {Elsevier},
  doi       = {10.1016/j.jbi.2026.105075},
  pmid      = {42419495}
}